Bioproduction and Biosynthesis of Prenylated Stilbenoids
Stilbenoids are plant defense phenolic compounds that exhibit numerous biological activities with potential applications in plant and human health. These compounds are present in non-taxonomically related plants species, such as grape and peanut. As many other defense compounds, most stilbenoids are either absent or accumulate in very low levels in non-stressed plants, thus highlighting the need to develop a sustainable system for their production. To address this issue, our laboratory has developed hairy root cultures of stilbenoid-producing species, including peanut and muscadine grape.
Different types of stilbenoids have been identified in hairy roots upon elicitor treatment. In particular, peanut hairy roots produce unique types of prenylated stilbenoids and their biosynthesis is being studied using a combination of targeted metabolic and transcriptomics approaches. Using this strategy, our group has identified the first stilbenoid specific prenyltransferases (AhR3’-DT1 and AhR4-DT1). These novel genes are being used in metabolic engineering studies to produce biologically active prenylated stilbenoids in different plant species.
Biological Activity of Prenylated Stilbenoids from Peanut
For further details about our research and collaborative projects check our publications and the following pending and issued patents: