Medina-Bolivar Laboratory

Harvesting a Healthy Future from Hairy Roots

Arkansas Biosciences Institute at Arkansas State University

Welcome

In the Medina-Bolivar lab we use hairy roots as bioproduction systems to discover natural products with important applications in human health.
Hairy roots are “immortalized” plant tissue culture systems that reproduce the biosynthetic capacity of intact plants. Using a combination of molecular, cellular and biochemical approaches, our research team has developed strategies to increase the levels of selected natural products in hairy roots by more than 1,000 times when compared to the parental plant. This patented technology allows for the sustainable production of compounds that are being tested for different bioactivities including anticancer, antiviral and anti-obesity properties. These bioassays are performed in our lab or through collaborative projects with institutions across the United States. We have an active group of undegraduate and graduate students, postdoctoral associates and research assistants. Over the years, the Medina-Bolivar laboratory has received funding from state, federal and private sources.

To learn about Dr. Fabricio Medina-Bolivar check his TEDx talk.

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What We Do

Research

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Teaching

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Publications & Patents

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Lab News

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Principal Investigator

Fabricio Medina-Bolivar, Ph.D.

Dr. Medina-Bolivar is native of Lima, Peru. He received his B.S. degree in Biology from Universidad Peruana Cayetano Heredia and title of Biologist for his research on plant tissue culture at the International Potato Center. He obtained his Ph.D. degree in Plant Physiology from the Pennsylvania State University and as part of his dissertation conducted research with hairy root cultures to study the biosynthesis of natural products. He did postdoctoral research on plant-based production of recombinant proteins at Virginia Tech.

Lab News
August 4, 2020

Medina-Bolivar Receives Technology Patent on “Stilbenoid prenyltransferases from plants.”

May 19, 2020

Virtual Accelerator Puts Early-Stage Companies on Path to SBIR/STTR Success

January 5, 2018

Our paper describing the first plant stilbenoid-specific prenyltransferases got published in the prestigious Journal of Biological Chemistry!