Publications & Patents

Publications
2020

Production of prenylated stilbenoids in hairy root cultures of peanut (Arachis hypogaea) and its wild relatives A. ipaensis and A. duranensis via an optimized elicitation procedure.

Authors:Fang L, Yang T (*), Medina-Bolivar F
Published: 2020
Molecules. 25(3):509. doi: 10.3390/molecules25030509. (*; First two authors share first authorship);
2019

Arachidin-1 and arachidin-3 modulation of rotavirus-infected MA104 cells

Authors:Witcher CM, Napier-Jameson R, Lockwood HN, Mattila MN, Wisdom SB, Saade Ferreira LL, Taylor J, Clack B, Medina-Bolivar F, Ball JM, Parr RD
Published: 2019
Journal of the American Council for Medicinally Active Plants. 8 (1): 1-19
2018

Stilbenoid prenyltransferases define key steps in the diversification of peanut stilbenoids

Authors:Yang T, Fang L, Sanders S, Jayanthi S, Rajan G, Podicheti R, Thallapuranam SK, Mockaitis K, Medina-Bolivar F.
Published: 2018
Journal of Biological Chemistry. 293: 28-46.
2017

Crossing kingdoms: Exploiting decellularized plants as pre-vascularized scaffolds for tissue engineering

Authors:Gershlak J, Hernandez S, Fontana G, Perreault L, Hansen K, Binder B, Larson S, Yang T, Dominko T, Rolle M, Weathers P, Medina-Bolivar F., Cramer C, Murphy W, Gaudette G
Published: 2017
Biomaterials. 125: 13-22

Biosynthesis and bioproduction of bioactive stilbenoids in hairy root cultures

Authors:Yang T, Fang L, Medina-Bolivar F
Published: 2017
In: Production of plant derived natural compounds through hairy root culture. Ed. Sonia Malik. Springer, Cham. pp. 45-64.
2016

A stilbenoid-specific prenyltransferase utilizes dimethylallyl pyrophosphate from the plastidic terpenoid pathway

Authors:Yang T, Fang L, Rimando A, Sobolev V, Mockaitis K, Medina-Bolivar F
Published: 2016
Plant Physiology. 171: 2483-2498

Perspectives of peanut phytoalexins: biosynthesis, bioproduction and their applications in human health

Authors:Condori J, Medina-Bolivar F
Published: 2016
In: Peanut bioactives and allergens. Eds. Alice Lee, Rao Rachaputi and Graeme Wright. DEStech Publications, Lancaster, USA. 47-81 pp
2015

Investigation of stilbenoids as potential therapeutic agents for rotavirus infections

Authors:Ball JM, Medina-Bolivar F, Defrates K, Hambleton E, Hulburt M, Fang L, Yang T, Nopo-Olazabal L, Atwill RL, Ghai P, Parr RD
Published: 2015
Advances in Virology. doi: 10.1155/2015/293524

Enhanced production of resveratrol, piceatannol, arachidin-1 and arachidin-3 in hairy root cultures of peanut co-treated with methyl jasmonate and cyclodextrin

Authors:Yang T, Fang L, Nopo-Olazabal C, Condori J, Nopo-Olazabal L, Medina-Bolivar F
Published: 2015
Journal of Agricultural and Food Chemistry. 63(15): 3942-3950
2014

Effect of light, methyl jasmonate and cyclodextrin on production of polyphenolic compounds in hairy root cultures of Scutellaria lateriflora

Authors:Marsh Z, Yang T, Nopo-Olazabal L, Wu S, Ingle T, Joshee N, Medina-Bolivar F
Published: 2014
Phytochemistry. 107: 50-60

Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana. Molecules

Authors:Zhai B, Clark J, Ling T, Connelly M, Medina-Bolivar F, Rivas F
Published: 2014
19(1): 756-766

Differential induction of antioxidant stilbenoids in hairy roots of Vitis rotundifolia treated with methyl jasmonate and hydrogen peroxide

Authors:Nopo-Olazabal C, Condori J, Nopo-Olazabal L, Medina-Bolivar F
Published: 2014
Plant Physiology and Biochemistry. 74: 50-69
2013

Antioxidant activity of selected stilbenoids and their bioproduction in hairy root cultures of muscadine grape (Vitis rotundifolia Michx.)

Authors:Nopo-Olazabal C, Hubstenberger J, Nopo-Olazabal L, Medina-Bolivar F
Published: 2013
Journal of Agricultural and Food Chemistry. 61(48): 11744-11758

Scutellaria: Biotechnology, Phytochemistry and its Potential as a Commercial Medicinal Crop

Authors:Joshee N, Tascan A, Medina-Bolivar F, Parajuli P, Rimando AM, Shannon DA, Adelberg JW
Published: 2013
n: Biotechnology for Medicinal Plants: Micropropagation and Improvement, Eds. Suman Chandra, Hemant Lata and Ajit Varma, Springer-Verlag, Heidelberg Germany. pp. 69-99
2012

Neuroprotective effect of peanut hairy root extract against oxidative stress in PC12 derived neurons

Authors:Prabhu P, Medina-Bolivar F, Condori J, Sivakumar G, Srivatsan M
Published: 2012
Journal of Medicinally Active Plants. 1(4): 125-133

Natural prenylated resveratrol analogs, arachidin-1 and -3, demonstrate an improved glucuronidation profile and have affinity for cannabinoid receptors

Authors:Brents LK, Medina-Bolivar F (*), Seely KA, Nair V, Bratton SM, Gallus-Zawada A, Nopo-Olazabal L, Patel RY, Liu H, Doerksen RJ, Prather P, Radominska-Pandya A
Published: 2012
Xenobiotica. 42: 139-156. [*First two authors share first authorship]

Super-promoter: TEV, a powerful gene expression system for tobacco hairy roots

Authors:Nopo L, Woffenden B, Reed D, Buswell S, Zhang C, Medina-Bolivar F
Published: 2012
(In: Recombinant Gene Expression: Reviews and Protocols, Third Edition, A. Lorence (Ed.), Springer). Methods in Molecular Biology. 824: 501-526
2011

Selection of reference genes for qPCR in hairy roots cultures of peanut

Authors:Condori J, Nopo-Olazabal C, Medrano G, Medina-Bolivar F
Published: 2011
BMC Research Notes. 4:392

Bioprocess and bioreactor: Next generation technology for production of potential plant-based antidiabetic and antioxidant molecules

Authors:Sivakumar G, Medina-Bolivar F, Lay J, Dolan MC, Condori J, Wright SM, Baque MDA, Lee E-J, Paek KY
Published: 2011
Current Medicinal Chemistry. 18: 79-90
2010

Induced biosynthesis of resveratrol and the prenylated stilbenoids arachidin-1 and arachidin-3 in hairy root cultures of peanut

Authors:Condori J, Sivakumar S, Hubstenberger J, Dolan MC, Sobolev VS, Medina-Bolivar F
Published: 2010
Effects of culture medium and growth stage. Plant Physiology and Biochemistry. 48: 310-318

Scutellaria biotechnology: achievements and future prospects

Authors:Joshee N, Parajuli P, Medina-Bolivar F, Rimando AM, Yadav AK
Published: 2010
Bulletin UASVM Horticulture. 67(1)/2010

Controlled production of stilbenoids in hairy root cultures of peanut (Arachis hypogaea)

Authors:Medina-Bolivar F, Condori J, Nopo-Olazabal C, Carrier J, Abbott J, Nair V, Atwill R, Baker J, Nopo-Olazabal L, Dolan M
Published: 2010
Polyphenols Communications. 1: 42-43

Purification of resveratrol, arachidin-1 and arachidin-3 from hairy root culture of peanut (Arachis hypogaea) and determination of their antioxidant activity and cytotoxicity

Authors:Abbott J, Medina-Bolivar F, Martin E, Engelberth AS, Villagarcia H, Clausen EC, Carrier DC
Published: 2010
Biotechnology Progress. 26(5): 1344-1351
2009

Plant-based small molecules and proteins: A source for natural medicines

Authors:Sivakumar G, Christopher S, Medina-Bolivar F, Uccella N
Published: 2009
In: Plant Secondary Terpenoids, Eds. Javier Palazon and Rosa Cusido, Research Signpost

Plant-based corosolic acid: Future anti-diabetic drug?

Authors:Sivakumar G, Vail D, Nair V, Medina-Bolivar F, Lay J
Published: 2009
Biotechnology Journal. 4: 1704-1711

Functional characterization of a stilbene synthase gene using a transient expression in planta

Authors:Condori J, Medrano G, Sivakumar G, Nair V, Cramer C, Medina-Bolivar F
Published: 2009
Plant Cell Reports 28: 589-599
2008

In vitro shoot culture and antimicrobial activity of Berberis buxifolia Lam

Authors:Pitta-Alvarez S, Medina-Bolivar F, Alvarez M, Scambatto A, Marconi P. 2008
Published: 2008
In Vitro Cellular & Developmental Biology. 44: 502-507

Expression of a ricin B:F1:V fusion protein in tobacco hairy roots: steps toward a novel pneumonic plague vaccine

Authors:Woffenden B, Nopo L, Cramer C, Dolan M, Medina-Bolivar F
Published: 2008
Electronic Journal of Integrative Biosciences. 3: 10-19
2007

Screening for bioactives stilbenes in the genus Nicotiana

Authors:Medina-Bolivar F, Nopo-Olazabal C, Nopo-Olazabal L, Sivakumar G, Condori J
Published: 2007
Recent Advances in Tobacco Science. 33:93-100

Production and secretion of resveratrol in hairy root cultures of peanut

Authors:Medina-Bolivar F, Condori J, Rimando A, Hubstenberger J, Shelton K, Bennett S, Dolan M
Published: 2007
Phytochemistry. 68: 1992-2003
2006

Rooting for new medicines In: J. Trauth and A. Romero (eds.). Adventures in the Wild: Tales from Biologists of the Natural State

Authors:Medina-Bolivar F
Published: 2006
The University of Arkansas Press. pp. 83-88
2005

Expression of porcine prorelaxin in transgenic tobacco

Authors:Buswell S., Medina-Bolivar F, Van Cott K, Zhang C
Published: 2005
Annals of the New York Academy of Sciences. 1041: 77-81

Purification and stabilization of ricin B from tobacco hairy root cultures by aqueous two phase extraction

Authors:Zhang C, Medina-Bolivar F, Buswell S, Cramer C
Published: 2005
Journal of Biotechnology. 117: 39-48
2004

Expression of functional hexahistidine-tagged ricin B in tobacco

Authors:Reed D, Nopo-Olazabal L, Woffenden B, Funk V, Reidy M, Cramer C, Medina-Bolivar F
Published: 2004
Plant Cell Reports. 24: 15-24

Production of recombinant proteins in hairy roots cultured in plastic sleeve bioreactors. In: Recombinant Gene Expression: Reviews and Protocols

Authors:Medina-Bolivar F, Cramer C
Published: 2004
P. Balbas and A. Lorence, (eds.). Humana Press, Totowa, pp 351-363

Camptothecin and 10-hydroxycampthotecin from Camptotheca acuminata hairy roots

Authors:Lorence A, Medina-Bolivar F, Nessler C
Published: 2004
Plant Cell Reports. 22: 437-441
2003

A non-toxic lectin for mucosal antigen delivery of plant-based vaccines

Authors:Medina-Bolivar F, Wright R, Sentz D, Barroso L, Wilkins T, Petri Jr. W, Cramer C
Published: 2003
Vaccine. 21: 997-1005
1998

Biosynthesis of constitutive versus inducible metabolites in hairy root cultures of Hyoscyamus muticus

Authors:Medina-Bolivar F, Flores H
Published: 1998
In: Radical Biology: Advances and Perspectives on the Function of Plant Roots. H.E. Flores, J.P. Lynch, D. Eissenstat (eds), American Society of Plant Physiologists, Rockville, MD, pp. 430-431
1995

Selection for hyoscyamine and cinnamoyl putrescine overproduction in cell and root cultures of Hyoscyamus muticus

Authors:Medina-Bolivar F, Flores H
Published: 1995
Plant Physiology. 108: 1553-1560

Root culture and plant natural products: “Unearthing” the hidden half of plant metabolism

Authors:Flores H, Medina-Bolivar F
Published: 1995
Plant Tissue Culture and Biotechnology. 1: 59-74

Studies on the manipulation of tropane alkaloid biosynthesis in hairy roots of Hyoscyamus muticus

Authors:Medina-Bolivar F, Flores H
Published: 1995
In: Phytochemicals and Health. D.L. Gustine and H. Flores (eds). American Society of Plant Physiology, MD. pp 297-299

Plant regeneration of sweet potato (Ipomoea batatas L.) from leaf explants in vitro using a two-stage protocol

Authors:Porobo Dessai A, Gosukonda R, Blay E, Dumenyo C, Medina-Bolivar F, Prakash C
Published: 1995
Sciencia Horticulturae. 62: 217-224
Patents

Stilbenoid Prenyltransferases from Plants

Inventors: Medina-Bolivar F, Yang T, Mockaitis T.
Issue Date: July 7, 2020

Method to increase the yield of products in plant material

Inventors: Medina-Bolivar F, Yang T
Issue Date: 12/04/2018

Method to increase the yield of products in plant material.

Inventors: Medina-Bolivar F, Yang T.
Issue Date: March 31, 2017

Therapeutic applications of prenylated stilbenoids against rotavirus infections

Inventors: Medina-Bolivar F, Parr R
Issue Date: Pending

Stilbenoid derivatives and their uses.

Inventors: Radominska-Pandya F, Prather P, Medina-Bolivar F, Mayeux P.
Issue Date: August 4, 2015

Production of stilbenes in hairy roots.

Inventors: Medina-Bolivar F, Dolan M, Bennett S, Condori J, Hubstenberger J.
Issue Date: February 23, 2010